....The Cannabinoids as Potential Antiepileptics..Os canabinóides como potenciais antiepilépticos..Los cannabinoides como posibles antiepilépticos....
Abstract: Comparative studies of the anticonvulsant properties of the cannabinoids and prototype antiepileptic drugs in numerous animal seizure models demonstrate that (1) as an anticonvulsant, cannabidiol (CBD), in contrast to Δ9-tetrahydrocannabinol (THC), is relatively selective in terms of both central nervous system (CNS) depressant and excitatory properties; (2) the potency of cannabidiol, unlike that of phenytoin and phenobarbital, varies greatly with the species; (3) the large potency difference between the cannabinoids and the antiepileptics in the mouse appears to be due to dispositional differences, because brain concentrations of all the drugs are very similar; (4) tolerance to the anticonvulsant properties of cannabidiol is not a prominent feature; in three seizure models, tolerance developed in one, but “reverse tolerance” developed in the other two; and (5) the results of a study of the electrophysiologic mechanisms of action indicate that cannabidiol produces some unique effects and that its spectrum of antiepileptic activity may be different from that of the prototype drugs. The anticonvulsant nature of cannabidiol suggests that it has a therapeutic potential in at least three of the four major types of epilepsy: grand mal, cortical focal, and complex partial seizures.
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- Dr. RALPH KARLER Ph.D.,
- STUART A. TURKANIS Ph.D.
This information is presented for educational purposes only. 1Pure. provides this information to provide an understanding of the potential applications of cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by 1Pure and none should be inferred.
....This information is presented for educational purposes only. 1Pure provides this information to give an understanding of the potential applications of cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by 1Pure and none should be inferred. ..Esta informação é apresentada apenas para fins educacionais. 1Pure fornece informações para dar uma compreensão das aplicações potenciais do canabidiol. Links para sites de terceiros não constituem um endosso dessas organizações por parte da 1Pure e nada deve ser inferido. ..1Pure proporciona información para dar una comprensión de las aplicaciones potenciales del canabidiol. Los enlaces a sitios de terceros no constituyen un endoso de estas organizaciones por parte de 1Pure y no se debe inferir nada. ....